Abstract
We synthesized an analogue of the thyromimetic GC-1 bearing the same hydrophobic appendage as the estrogen receptor antagonist ICI-164,384. While having reduced affinity for the thyroid hormone receptors compared to GC-1, it behaves in a manner consistent with a competitive antagonist in a transactivation assay.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Acetates*
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Binding, Competitive
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Biphenyl Compounds / chemistry*
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Biphenyl Compounds / pharmacology
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Carboxylic Acids / chemistry*
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Carboxylic Acids / pharmacology
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Crystallography, X-Ray
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Molecular Structure
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Phenols*
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Receptors, Thyroid Hormone / antagonists & inhibitors*
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Receptors, Thyroid Hormone / metabolism
Substances
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Acetates
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Biphenyl Compounds
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Carboxylic Acids
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GC 1 compound
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Phenols
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Receptors, Thyroid Hormone